For example, an 8 oz glass of water with enzymes can be helpful. Freedman: Actually, some fluid with enzymes is helpful as enzymes need some fluid to dissolve well. Does drinking a glass or so of water when eating a meal cause the enzymes to move through the stomach faster (wash the enzymes away before they can start working)?ĭr. The amount of fat in a meal or snack affects the amount of enzyme needed. There is no magic formula or medication guide and each person may be different. Severe: 5-7 or up to 9 capsules/meal and 3-5/snackĪ meal with a very high fat content might require 9-12 capsules.Moderate: 2-5 capsules/meal and 2/snack.A typical dose based on severity of EPI is as follows (may vary by patient): However, the pancreas does not secrete based on a person’s weight but based on the food that is ingested. The FDA approval is based on body weight. Is dosing based on the size of a meal or amount of fat? Are these just ballpark doses? A question about pancreatic enzyme dosing: For an adult the dosing recommendation is 500 lipase units per kg/meal and 250 lipase units per kg/meal. If the meal is taking longer than expected, they need to take more enzymes to match enzymes with food. Therefore, a person should consider how long it will take to eat a meal and what they are eating and take the appropriate enzymes. Freedman: The goal is to mimic the actions of a healthy pancreas and a healthy pancreas will release more enzymes with more fat. At what part of the meal or snack should I take my enzymes?ĭr. How do I take pancreatic enzymes for EPI? How many enzyme pills should I take? For more information on the recommended dosing of enzymes for adults, watch our video. įor a comprehensive summary of exocrine pancreatic insufficiency, visit our page dedicated specifically to EPI. Freedman answers patients’ questions about EPI. We had so many questions during the webinar that we could not get to them all. If you missed the webinar, you can watch it here. For a more comprehensive overview of EPI, please read this article.Įnzymes and PERT are a confusing but critically important part of chronic pancreatitis treatment. EPI is one of the symptoms of pancreatitis. Steven Freedman, MD, Ph.D., a worldwide expert on pancreatic disease and cystic fibrosis, presented on Mission: Cure’s Pancreatitis Patient Webinar on Exocrine Pancreatic Insufficiency (EPI) and Pancreatic Enzyme Replacement Therapy (PERT). Steven Freedman of Beth Israel Deaconess Medical Center and Harvard Medical Schoolĭr.
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